Zolpidem (Ambien),a nonbenzodiazepine hypnotic.AMBIEN contains zolpidem tartrate,
a gamma-aminobutyric acid (GABA) A receptor positive modulator of the imidazopyridine
class. AMBIEN is available in 5 mg and 10 mg strength tablets for oral administration.
It has a chemical formulae of zolpidem N,N,6-trimethyl-2-p-tolylimidazo[1,2-a]
pyridine-3-acetamide L-(+)-tartrate (2:1). Zolpidem (AMBIEN) acts as a typical Central Muscle relaxant and has anti convulsant effects.
Zolpidem (AMBIEN) has become the most widely prescribed sleep aid in the
United States as it is indicated for the short-term treatment (up to 4 weeks)
of insomnia,Reduces the Number of Night Awakenings,increases sleeping time
and increases its quality and efficiency.
Before deciding to Buy Ambien online it is always important
to carefully read the Contraindications and consult your Doctor before use.
Zolpidem (AMBIEN) has the following Contraindications:confused,
having thoughts of suicide,alcohol intoxication,drug abuse,depression,
aggressive behavior,Attention Deficit Disorder with Hyperactivity,
Myasthenia Gravis,Severe Chronic Obstructed Lung Disease,
liver problems,severe liver disease,Loss of Memory,
Hallucination,Temporarily Stops Breathing While Sleeping,Weakened Patient,
Perform Complex Natural behaviors while Asleep,
Child hood and Adolescence.Sensistivity and allergic to Zolpidem.
Before deciding to Buy AMBIEN Online Individuals should take note of the following side effects:
-Amnesia shortly after ingestion and into their sleep cycle
-Some Indidviduals may experience 1 to 7 hours of visual Hallucination
after taking Zolpidem.
-At the level of the digestive system some Patients may experience
Indigestion,Nausea,Vomiting and Diarrhea.
-Less common effects have also been reported, including lack of bladder
control, lack of coordination, ringing inside the ears, inflammation of the sinus,
speech problems,lethargy,light-headedness, loss of appetite,vision problems,
nightmares, amnesia, anxiety, arthritis, sensitivity to light,
sleepwalking, and speech difficulties.
-Ambien Zolpidem has some rare side effects like violation of
sexual Desire,Addiction,high physiscal and psychic dependence.
Zolpidem Ambien is strictly Contraindicated for Pregnancy and Lactation(Breast feeding)
Zolpidem,like other sedative drugs,has a CNS-depressant effect,and caution
should be used when it is administered with other CNS depressants.
An additive effect on psychomotor performance between alcohol and zolpidem has been demonstrated.
Many patients who suffer from depression also have bouts of insomnia.
Insomnia may also be induced by selective serotonin reuptake inhibitors,
although this appears to be different from and in addition to that most often associated with depression.
The pharmacokinetic and pharmacodynamics interactions between zolpidem (10 mg) and fluoxetine (20 mg).
The study concluded that the onset of action of zolpidem may be shortened with the co-administration with fluoxetine.
Another study of 29 healthy female subjects who were taking both zolpidem and
fluoxetine (Prozac) showed only minor pharmacokinetic changes compared with
zolpidem alone. However,in a similar study undertaken to determine whether there
are pharmacokinetic interactions between zolpidem (10 mg) and sertraline (Zoloft)
(50 mg), coadministration appeared to be safe in healthy females (n=28),but may result
in shortened onset of action and increased zolpidem effect. Higher drug concentrations
of zolpidem were detected over a short time, leading to a quicker onset of action
and increased effect of zolpidem.
In 1998, Greenblatt et al. (54) investigated the kinetic and dynamic interaction
of zolpidem with the antifungal agents ketoconazole,itraconazole,and fluconazole.
They determined that coadministration of zolpidem with ketoconazole impaired the
clearance rate of zolpidem and enhanced its benzodi- azepine-like effects.
The other agents had only a small influ- ence on zolpidem effects.
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